Cancer development and immune defense

Theme leader: Joop Jansen

Our primary goals are to gain insight into the molecular, genetic and epigenetic processes that lead to the transformation of normal (stem) cells to malignant cancer cells. The knowledge gained on tumor microenvironment and interactions between the immune system and cancer is translated into the development of specific forms of therapy, targeting the affected molecular pathways, and by using (modified) immune cells targeting the tumor cells.

Keywords: Molecular carcinogenesis; Stem cell Biology; Hemato-oncology; Melanoma; Ovarian Cancer; Immunity against cancer; Dendritic cells; T cells; NK cells; Cellular therapy; Cancer vaccination

 

Theme news

Next theme events

Mar 8 - Mar 8
Seminar: Stefan LinderRegulation of actomyosin contractility at macrophage podosomes
Mar 8 - Mar 8
Graduation: Steve BoudewijnsDendritic cell vaccination in the evolving therapeutic landscape of melanoma
Mar 27 - Mar 27
Cancer Immunology and Immunotherapy meetingTopic: Tumor microenvironment

Related assistant / associate / full professors

Adema, Gosse
Adema, GosseCurrent research interests include the analysis of dendritic cells and Myeloid- and T-regulatory cells, and their function in the immune system in health and disease. read more >>
Bogaart Geert vd
van den Bogaart, GeertExocytosis in immune cells.read more >>
Dolstra, Harry 2016.jpg
Dolstra, HarryImmune regulation and modulation of the graft-versus-tumor responses after stem cell transplantation.read more >>
Figdor, Carl
Figdor, CarlMolecular mechanisms controlling antigen presenting cells, in particular dendritic cells.read more >>
Friedl Peter
Friedl, PeterCell-matrix interactions & dynamic cell patterning during immune cell interactions and tumour invasion.read more >>
Hobo, Willemijn-2015.jpg
Hobo, WillemijnDevelopment and improvement of immunotherapies to boost anti-tumor immunity in cancer patients.read more >>
Hoogerbrugge Peter 2014
Hoogerbrugge, PeterBiology of childhood acute lymphoblastic leukemia (ALL) from both 'clinical' and ‘bench' perspectives. read more >>
Hooijmans, Carlijn
Hooijmans, Carlijnread more >>
Huls, Gerwin
Huls, Gerwin Translational hematology, MDS, AMLread more >>
Jansen, Joop
Jansen, JoopMolecular mechanisms implicated in human leukemia and myelodysplastic syndromes.read more >>
Kamminga , Leonie 2013
Kamminga, LeonieResearch aims to unravel epigenetic mechanisms regulating cellular identity during developmentread more >>
Krieken , Han Van 2014
van Krieken, HanResearch interests focus on the understanding of the development of cancer.read more >>
Leeuwen Frank N Van
van Leeuwen, FrankThe mission our laboratory is to investigate the cell biology and genetics of childhood malignancies.read more >>
Martens, Joost
Martens, JoostTranscriptional and epigenetic factors associated with oncofusion protein expression.read more >>
Mulder, Klaas
Mulder, KlaasMy lab investigates the mechanisms underlying human epidermal stem cell renewal & differentiation.read more >>
Reijden, Bert van der
van der Reijden, BertMolecular biology of leukemia, especially transcriptional regulation and protein ubiquitination.read more >>
Scheijen, Blanca.jpg
Scheijen, BlancaMolecular pathogenesis of lymphoid malignancies and novel mechanisms of therapy resistanceread more >>
Spriel Annemiek Van
van Spriel, AnnemiekScientific interests include plasma membrane organization of antigen-presenting cells.read more >>
Stunnenberg
Stunnenberg, HenkOur research aims at unravelling gene regulatory networks in human, mouse & malaria.read more >>
Veenstra, Gert Jan 2016.jpg
Veenstra, Gert-JanResearch aims to elucidate gene regulation mechanisms during early vertebrate embryogenesis.read more >>
Vermeulen , Michiel2
Vermeulen, MichielProteomics and Chromatin Biologyread more >>
vries de, Jolanda 2016.jpg
de Vries, JolandaResearch interests include immunotherapy of cancer, in particular dendritic cell vaccination.read more >>

Involved departments

Publications highlights