The research focus is on tumor cell invasion, a process facilitated by proteolytic processing of the heterogeneous extracellular matrix. The aim is to (a) identify the extracellular recruitment and cleavage-control mechanisms of MT1-MMP, the most important tumor-associated pro-invasive cell surface protease; (b) define the physical limits and the limiting cell compartments (i.e. nucleus) for protease-independent cancer cell migration through 3D tissues in vitro; and (c) validate the relevance of protease-dependent and -independent (drug-induced) tumor invasion modes and metastasis in vivo.
Katarina Wolf obtained her PhD in cell biology and biochemistry at the University of Wuerzburg, Germany (2003) under the supervision of Prof. P. Friedl. After working as a postdoc at the University of Wuerzburg and at the NCMLS, she received a VIDI grant from the Netherlands Organization for Scientific research (NWO) in 2009, and currently holds a tenure track position at the Department of Cell Biology. Her research focusses on proteolytic and non-proteolytic mechanisms of tumor invasion.
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