Daniela Wilson

Wilson , Daniela -2
Name:
Prof. Daniela Wilson 


Function:
Full Professor


Theme:
Nanomedicine



Profile

Biological motors have always inspired scientists in their quest to mimic the directional movement and efficiency of biological systems. Since the famous Fantastic Voyage movie, futuristic visions have emerged of building "tiny cars", "aircrafts" or "submarines" as small as bacteria or microscopic surgeons able to reach infected organs and cure diseases. Current nanoparticles based targeting drug delivery paradigms rely heavily on the blood flow to distribute and dispense the therapeutic agents. The efficiency of such delivery systems is still very limited largely due to the fact these structures rely almost exclusively on passive accumulations in the tumor tissue, leading to severely limited treatment efficiency and undesired side effects. The aim of our group is to develop truly active delivery systems for chemoterapeutics by designing intelligent, self-propelled and self-guided supramolecular nanomotors capable of following the specific chemical concentration gradients generated by diseased tissue via chemotaxis. We are also interested in expanding the scope of self-assembled catalytic nanomotors towards biological fuels, which would allow the realization of biologically compatible nanorockets circumnavigating the biological world as well as developing nanomotors for which their structure and function can be manipulated by external fields and stimuli for sensory devices.

Daniela A. Wilson received her PhD with "summa cum laudae" from "Gh. Asachi" Technical University of Iasi, Romania after performing two exchange research programs in Japan and UK. She then moved to University of Pennsylvania, Philadelphia, USA as a post-doctoral researcher. In 2012 she was awarded an ERC starting grant to establish an independent research group investigating nanomotors with autonomous propulsion in biological systems. She is now assistant professor at the Institute for Molecules and Materials at Radboud University Nijmegen. Her research interests span a broad range of topics at the interface of supramolecular chemistry, macromolecular chemistry, and nanotechnology.


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