Scientific interests include immunology at the cellular and molecular level with a major focus on the plasma membrane organization of antigen-presenting cells. Tetraspanin proteins coordinate the spatial organization of specific immunoreceptors and signaling molecules into 'tetraspanin microdomains'. We discovered that tetraspanins are critically involved in immune cell function, including antigen presentation, proliferation and antibody production. The aim of our research is to unravel the molecular mechanisms that underlie tetraspanin microdomain function in immune cells in relation to the development of malignant disease.
Dr. Annemiek van Spriel is a tenured senior scientist at the Department of Tumor Immunology. She pursued a long-term Post-Doctoral Fellowship in the Leukocyte Membrane Laboratory of Ass. Prof. Mark Wright (Burnet Institute, Melbourne, Australia). In 2004, she joined the Tumor Immunology Department in the NCMLS where she obtained Grants from The Netherlands Organization for Scientific Research (NWO) and the Dutch Cancer Society (KWF) to establish her own research line that is focused on investigating tetraspanins in immune cells in relation to the development of cancer.
In 2012, she has been awarded the prestigious NWO-Vidi Grant for her work on tetraspanin proteins in the immune system. In 2016, Annemiek van Spriel has been awarded the ERC consolidator grant (2M Euro) to investigate Tetraspanin proteins on tumour cells.
National & International Personal Prizes & Awards
2007: Dutch Cancer Society (KWF) Grant 'Tetraspanin CD37 in the battle against cancer' (472,000 Euro).
2007: NWO-ALW Open Program Grant; 'The importance of tetraspanin proteins in membrane organization' (205,633 Euro).
2010: NCMLS Talent event PhD fellowship. 'Tetraspanin dynamics in the plasma membrane of living immune cells' (240,000 Euro). International PhD talent recruitment program in Molecular life sciences.
2011: Innovation Grant of the Dutch Kidney Foundation 'Tetraspanin CD37: a novel player in IgA nephropathy' (100,000 Euro).
2012: Vidi Grant (NWO) 800.000 Euro for her work on tetraspanin proteins in the immune system. 'Connecting the network: tetraspanin platforms in immune cell signaling'.
2012: NWO-MEERVOUD Grant Laureate
2013: Aspasia Grant (NWO) 100.000 Euro for her work on Tetraspanins in the immune system.
- 2016: ERC consolidator grant (2M Euro) to investigate Tetraspanin proteins on tumour cells.
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