Roland Kuiper is a molecular biologist with a research focus on cancer genomics. Aim of his research is to identify and characterize novel genomic abnormalities in relation to cancer risk and development, with a particular focus on hereditary (gastrointestinal) cancer and childhood leukemia. Current projects involve the identification of novel cancer predisposing genes and (epi)genetic mechanisms in families with a high, but unexplained, risk of gastric and colorectal cancer and in patients with malformation syndromes and cancer. Previous findings include the discovery of a new epigenetic silencing mechanism in hereditary colorectal cancer. In 2009, he was awarded with a ZONMW VIDI grant on heritable epimutations in colorectal cancer predisposition. Another project focuses on the characterization of recurrent genomic abnormalities (copy number alterations, acquired uniparental disomy, somatic mutations) involved in initiation and progression of acute lymphoblastic leukemia in children, particularly in relation to relapse, therapy resistance and overall outcome. Recently, the IKZF1 gene was identified as a novel prognostic biomarker in childhood acute lymphoblastic leukemia, which is currently being implemented in routine diagnostics.
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