Leonie Kamminga

Kamminga , Leonie 2013
Name:
Dr. Leonie Kamminga 


Function:
Assistant Professor


Theme:
Cancer development and immune defense



Profile

During early embryonic development different tissues have to be specified and subsequently it is important that the identity of these tissues are maintained. Tight control of these processes is necessary to be able to form a well-functioning organism. This requires proper regulation of gene expression. Since all cells in a multi-cellular organism have the same DNA content, this control has to be on a higher level. This is done through chromatin: the complex of DNA wrapped around an octamere of histones plus associated proteins. Proper control of the chromatin structure forms the basis of cellular identity. Polycomb group (PcG) proteins can change the chromatin structure, resulting in a repressive effect on gene transcription. Using zebrafish as a model system, we aim to elucidate how PcG proteins are involved in controlling tissue specification and maintenance. These studies contribute to our understanding of mechanisms that are essential for normal and abnormal development.

Leonie Kamminga is assistant professor at the department of Molecular Biology. She obtained her PhD in Groningen. She did her post-doctoral training at the Hubrecht Insitute in Utrecht where she worked on the identification and characterization of a new class of germline specific small RNAs called piwi-interacting RNAs (piRNAs). After obtaining a VENI grant from the Netherlands Organization for Scientific Research (NWO), she started doing research on the epigenetic regulation of development. She moved to Nijmegen as a recipient of the RUNMC tenure-track research fellowship.


National & International Personal Prizes & Awards

  • VENI fellowship from the Netherlands Organization for Scientific Research (NWO)
  • RUNMC tenure-track research fellowship
  • VIDI grant from the Netherlands Organization for Scientific Research (NWO).

Secondary functions

None


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