Research in our group aims at the development of new drug delivery strategies for oligonucleotides, peptides and proteins. In particular, we are interested in the mechanisms by which so-called cell-penetrating peptides (CPP) enter cells and in the application of these peptides for drug delivery.
Cellular drug delivery is a two-sided relationship of the drug delivery vector and the capacity of the cell to respond to this vector and induce uptake without toxicity. Therefore, we combine research on the design of CPP and carriers for oligonucleotide delivery with research on the biochemical details of the interaction of these carriers with cells, and the cellular signal transduction mechanisms that are involved in uptake.
This research uses a broad spectrum of techniques ranging from the physicochemical characterization of oligonucleotide complexes to high-resolution confocal microscopy and animal experiments.
Roland Brock holds the chair of Biochemistry of Integrated Systems in the department of Biochemistry. Since 2007 he is also head of the Department of Biochemistry. In addition to pursuing interests in basic science, his group has been involved in numerous collaborations with biotech companies and the pharmaceutical industry.
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