Richard Bartfai

Bartfai, Richard
Name:
Dr. Richard Bartfai 


Function:
Assistant Professor


Theme:
Infectious diseases and global health



Profile

Malaria, caused by unicellular eukaryotic parasites of the Plasmodium genus, claims the life of about a million people every year, the majority of whom are children or pregnant women. Although gene regulatory, and in particular epigenetic, mechanism unique to the parasite could provide potential targets for drug based intervention, we know very little about these processes. My research group aims to decipher transcriptional and epigenetic mechanisms that govern the development of P. falciparum in the human red blood cells. We use state-of-the-art genomic approaches (e.g. ChIP-seq) to profile the genome-wide distribution of epigenetic features (histone variants, histone post-translational modifications, nucleosome positioning, chromatin modifying enzymes) as well as DNA-binding proteins. These genome-wide maps together with complementary sets of proteomic and biochemical experiments are expected to provide the necessary insight into gene regulatory mechanism of the malaria parasite and important clues for the development of antimalarials compounds.

Richard Bartfai obtained his PhD from the National University of Singapore and studied gene regulatory mechanism that govern the development of male and female gonads in zebrafish. In 2007 he joined the department of Molecular Biology at Radboud University Nijmegen as a postdoctoral fellow and deciphered the basic organization of the Plasmodium epigenome. Recently he obtained the prestigious NWO-VIDI grant as well as a (sub)grant from NIH (EuPatDB) and now leads his own research group.


Secondary functions

None


<< go back