The underlying molecular mechanisms of PKC signaling in B cells are only partially resolved. Malou Zuidscherwoude and Vera Dunlock, group of Annemiek van Spriel, Dept. of Tumor Immunology, theme Cancer development and immune defense, now discovered that in response to B cell receptor stimulation, PKCb was specifically recruited to plasma membrane microdomains containing tetraspanin CD53.
Mouse or human B cells deficient in CD53 showed impaired PKCb activation and reduced phosphorylation of its targets, indicating that tetraspanin microdomains act as signaling platforms for the activation of PKC in B cells.
Malou Zuidscherwoude Vera Dunlock
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