Seminar: Daphne Weihs

Mechanobiology of cancer invasion and wound healing

Date:
2 May 2017 12:00 hrs. - 13:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Mechanobiology of cancer invasion and wound healing
Speaker(s):

Daphne Weihs, Biomedical Engineering, Technion-Israel, Institute of Technology, Haifa, Israel

Host(s):

Katarina Wolf, Dept. of Cell Biology, RIMLS

02-05-2017 12:00:0002-05-2017 13:00:00Europe/AmsterdamMechanobiology of cancer invasion and wound healing Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedOur focus is on the  mechanobiology  of  (1) invasive  cancercells  and  (2)  wound  healingMetastatic cells must change shape and apply forces to invade. Mechanobiology highlights differences of metastatic cells from benign, revealing mechanically invasive subpopulations. We also test the use of mechanobiologal approaches to accelerate wound healing, e.g. by mechanical stretching. 

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Key Publications 

  • Metastatic cancer cells tenaciously indent impenetrable, soft substrates, New J Phys 15, 035022, 2013
  • Low-level stretching accelerates cell migration into a gap, Int Wound J, 2016
  • Cell-gel mechanical interactions as an approach to rapidly and quantitatively reveal invasive subpopulations of metastatic cancer cells. Tissue Eng C, 2017


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